What Is Letrozole?

Letrozole, sold under the brand name Femara, is a non-steroidal aromatase inhibitor (AI) that reduces estrogen levels by blocking the enzyme aromatase. This enzyme is responsible for converting androgens (like testosterone) into estrogen. Letrozole is commonly used in hormonal therapy, especially for post-cycle therapy (PCT) or managing estrogen-related side effects from steroids or other performance-enhancing drugs (PEDs).

At 2.5mg per tablet, Letrozole is typically prescribed for treating breast cancer in women, but bodybuilders use it to prevent estrogenic side effects such as gynecomastia (man boobs), water retention, and bloating.

💊 Dosage Guidelines

Use Case	Dosage (Daily)	Notes
Estrogen Control (on-cycle)	2.5mg every other day	Start low, adjust based on estrogen levels
Gynecomastia Prevention	2.5mg every other day	Typically sufficient for most users
Post-Cycle Therapy (PCT)	2.5mg every day (early phase)	Adjust dosage based on recovery needs
Estrogenic Side Effects	1.25–2.5mg every other day	Taper off once symptoms subside

🕒 Half-Life: 2–4 days
💊 Frequency: Usually every other day to avoid over-suppressing estrogen
🔬 Monitor Estrogen: Always get bloodwork to ensure you’re not over-suppressing estrogen (can lead to joint pain, fatigue, etc.)

💪 Benefits of Letrozole (Femara) 2.5mg

Benefit	Intensity
Reduces Estrogenic Sides	⭐⭐⭐⭐⭐
Prevents Gynecomastia	⭐⭐⭐⭐⭐
Prevents Water Retention	⭐⭐⭐⭐⭐
Clears Bloat/Hardens Muscles	⭐⭐⭐⭐
Supports Natural Testosterone Production	⭐⭐⭐⭐