🔬 YK‑11 – Research Use Only
🧪 Chemical Identity
-
Name: YK‑11 (Methyl (2E)-…acetate)
-
Synonyms: Myostine; 17α‑methyl‑δ²‑17β‑hydroxyestra‑4,9‑dien‑3‑one
-
CAS No.: 1370003‑76‑1; Formula: C₂₅H₃₄O₆ reddit.com+15en.wikipedia.org+15reddit.com+15
⚙️ Mechanism of Action
-
Steroidal SARM/analogue: Binds androgen receptors (AR) as a partial agonist—unlike full agonists, it does not support classic N/C terminal interactions pathofpeds.com+5en.wikipedia.org+5wikibolics.com+5.
-
Myostatin inhibition: Upregulates follistatin, reducing myostatin activity and promoting muscle differentiation in vitro pubmed.ncbi.nlm.nih.gov+10en.wikipedia.org+10publichealthlaw.net+10.
🔬 Research Applications & Evidence
-
Enhanced muscle development: Improved growth in C2C12 myoblasts; superior anabolic activity vs. DHT in lab settings reddit.com+15en.wikipedia.org+15publichealthlaw.net+15.
-
Bone health potential: May support osteoblast proliferation/mineralization, signaling through Akt pathway publichealthlaw.net+1steroiduck.com+1.
-
Neurochemical effects: Animal study (~350 mg/kg in rats for 5 weeks) found hippocampal inflammation, oxidative stress, and memory impairments reddit.com+7pubmed.ncbi.nlm.nih.gov+7chemicalbook.com+7.
⚠️ Safety & Side Effects
-
No approved clinical data: No human or formal animal clinical trials exist steroiduck.com+6selfhacked.com+6musclemastery.net+6.
-
Potential liver toxicity: Derived from steroid structure; hepatotoxicity is a concern reddit.com+8sarms.io+8musclemastery.net+8.
-
Hormonal suppression: Likely stronger than non-steroidal SARMs—common testosterone suppression noted nanotechproject.org+5musclemastery.net+5sarms.io+5.
-
Joint/tendon issues: Frequently reported by users steroiduck.com+15sarms.io+15anabolica.net+15.
-
Neurological risk: Anxiety, aggression, and potential panic; inflammation and oxidative stress in neuronal tissue .
⚠️ Regulatory & Ethical Notice
-
Research-only substance: Not approved by FDA for human or veterinary use. Must include “Not for human use” on all documentation.
-
Banned in sports: Listed on WADA’s prohibited list sarms.io+2selfhacked.com+2musclemastery.net+2.
-
Unregulated gray-market risks: Purity and accurate labeling are not guaranteed outside certified lab suppliers selfhacked.com+2musclemastery.net+2pathofpeds.com+2.
🛠️ Handling & Storage Guidelines
-
Form: ≥98 % purity research-grade powder or oral/injectable solution.
-
Dosage (anecdotal only): 5–15 mg/day orally, often split doses; injectable dosing unstudied and potential for injection-site risks reddit.com+15selfhacked.com+15wikibolics.com+15.




Reviews
There are no reviews yet.