CJC-1295 No DAC

CJC-1295 No DAC (Mod GRF 1-29) — Short-Acting GHRH Analog Research Peptide

CJC-1295 No DAC — also known as Modified GRF (1-29) or Mod GRF 1-29 — is a research-grade short-acting GHRH analog (CAS 863288-34-0) comprising the first 29 amino acids of human GHRH with four strategic amino acid substitutions (Ala2→D-Ala, Gln8→Ala, Ser15→Ala, Leu27→Ala) that resist enzymatic degradation and extend plasma half-life to approximately 30 minutes — producing sharper, more physiological pulsatile GH release patterns than long-acting analogs like CJC-1295 DAC. This makes it the preferred compound for studies requiring GH pulse modeling, endogenous rhythm studies, or combination protocols with GHRPs.

What Is CJC-1295 No DAC (Mod GRF 1-29)?

• Pulsatile GHRH receptor agonism — stimulates pituitary GH release in physiological burst pattern
• ~30 min plasma half-life — 4-substitution stability without albumin-binding DAC modification
• GH/IGF-1 axis activation — dose-dependent GH and downstream IGF-1 increase in rodent models
• GHRP synergy — potent synergistic GH release when combined with ipamorelin or GHRP-2/6
• Physiological GH pulsatility modeling — replicates natural GH pulse patterns vs. sustained release of DAC variants
• Enzymatic stability research — dipeptidyl peptidase IV (DPP-IV) resistance vs. native GHRH