Tesamorelin 10mg — FDA-Referenced GHRH Analog Research Peptide
Tesamorelin 10mg is a research-grade stabilized synthetic analog of growth hormone-releasing hormone (GHRH) (CAS 218949-48-5), distinguished by the addition of a trans-3-hexenoic acid group at the N-terminus to enhance stability. Tesamorelin is one of the most clinically-referenced synthetic GHRH analogs in existence, having received FDA approval under the trade name Egrifta® for HIV-associated lipodystrophy — making it one of the few research peptides with a validated human clinical data set. It is studied for GH/IGF-1 axis activation, visceral adipose tissue reduction, and GHRH receptor pharmacology.
What Is Tesamorelin?
- GHRH receptor activation — stimulates pituitary GH release via GHRH-R with preserved pulsatility
- GH/IGF-1 axis modulation — dose-dependent increases in GH and IGF-1 in clinical and pre-clinical models
- Visceral adipose tissue reduction — FDA-validated mechanism for lipodystrophy-associated visceral fat accumulation
- Metabolic pathway research — insulin sensitivity, lipid metabolism, and adipokine signaling studies
- Cognitive function studies — GH/IGF-1-mediated neuroprotective and cognitive research models
- N-terminal stabilization chemistry — trans-3-hexenoic acid modification for plasma stability vs. native GHRH
Common Research Applications
Tesamorelin 10mg (CAS 218949-48-5) is used in professional pre-clinical research for:
- GHRH receptor agonism and GH secretion pathway studies
- IGF-1 axis signaling and downstream anabolic pathway research
- Visceral adipose tissue metabolism and lipodystrophy models
- Metabolic syndrome and insulin sensitivity research
- GH-mediated cognitive function and neuroprotection models
- Comparative GHRH analog pharmacology (vs. CJC-1295, native GHRH)
- N-terminal peptide stabilization chemistry research
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