Sermorelin 10mg

Sermorelin 10mg — GHRH (1-29) Research Peptide

Sermorelin 10mg is a research-grade synthetic analog of growth hormone-releasing hormone (GHRH) comprising the first 29 amino acids of endogenous human GHRH (CAS 86168-78-7, 3357.88 g/mol) — the biologically active N-terminal fragment responsible for pituitary GH stimulation. Unlike CJC-1295 variants, sermorelin preserves the native GHRH(1-29) amino acid sequence without additional substitutions, providing a natural-sequence research model for GHRH receptor activation and pulsatile GH release physiology. Sermorelin is the closest research analog to endogenous GHRH available for pre-clinical GH axis studies.

What Is Sermorelin?

• Native GHRH(1-29) sequence — first 29 amino acids of human GHRH without additional substitutions
• Pituitary GHRH-R agonism — stimulates somatotroph GH release via hypothalamic-pituitary GHRH receptor
• Pulsatile GH release — produces physiological GH burst pattern preserving normal GH axis feedback
• GH/IGF-1 axis activation — dose-dependent GH and downstream IGF-1 increases in pre-clinical models
• Native sequence pharmacology — comparison vs. modified GHRH analogs (CJC-1295, tesamorelin)
• Somatostatin feedback modeling — natural GHRH/somatostatin axis balance studies